PROTOCOL COMPARISON — MEDICATION ABORTION

FDA Approved Regimen
(Based on evidence up to 1996)
Alternative Evidence-Based Regimen
(Based on current evidence)
Oral Misoprostol Buccal Misoprostol Vaginal Misoprostol

Gestational age:
Up to 49 days after first day of last period

Gestational age:
Up to 63 days after first day of last period

Gestational age:
Up to 63 days after first day of last period

Mifepristone 600 mg.
(swallowed in the office)
Mifepristone 200 mg.
(swallowed in the office)
Mifepristone 200 mg.
(swallowed in the office)

Misoprostol 400 mcg.

Oral use

Swallowed in the office
48 hours after taking mifepristone

Misoprostol 800 mcg.

Buccal use

Used at home 24-48 hours after taking mifepristone
Put in the cheek to melt

Misoprostol 800 mcg.

Vaginal use

Used at home 6-72 hours after taking mifepristone
Put in the vagina

Office follow-up 10-15 days after taking mifepristone Office follow-up 4-14 days after taking mifepristone Office follow-up 4-14 days after taking mifepristone
3 office visits 2 office visits 2 office visits